Cells become senescent in response to damage, a toxic environment, the signaling of nearby senescent cells, or, most commonly, because they reach the Hayflick limit on replication. Senescent cells cease replication and begin to secrete pro-inflammatory signals, attracting the attention of the immune system. With advancing age he aged immune system becomes less able … Read more
Inducing Low Body Temperature via Torpor Slows Aging in Mice Past evidence has suggested that the lowered body temperature characteristic of calorie restriction is important to the slowed aging that results in short-lived mammals. One might compare that to the strong evidence for upregulated autophagy to be the driving factor in slowed aging produced … Read more
Blowing your nose to oblivion without dislodging any of the snot clogging it is the physiological equivalent of screaming into the void: Sheer force won’t change the reality of what you’re dealing with. In the blocked-nose situation, at least, you’ve got other options. There are easy, effective ways to help you inhale normally, even when … Read more
In today’s open access paper, researchers here look at some of the proximate causes of transposable element activation, the details of the epigenetic and transcriptional issues. It is well known that transposable element activity increases with age. These are sequences capable of self-replication in the genome, the remnants of ancient retroviral infections. Transposon activity … Read more
Plus, when you bring up relationship concerns or life logistics on the fly, there’s a good chance you won’t effectively hear one another. “You can miss what each other’s saying because you’re not primed for attentive listening or you feel infringed upon—like, there you are trying to have your moment and someone is poking at … Read more
You might not think of spring as a great season for shopping, but after scoping out the best Amazon Memorial Day sales, we’re convinced that the month leading up to this holiday is the perfect time to find deals on items you may have already been eyeing. Whether you’re looking for a Mother’s Day gift, … Read more
The month of May ushers in two glorious events: The unofficial start of summer and amazing Memorial Day sales. It might feel a little early to start thinking about Memorial Day weekend, but many of the holiday deals are already live, and these are some of the best discounts you’ll find in the first half … Read more
There is a continuing debate over the degree to which Alzheimer’s is driven by persistent infection in brain tissue, such as by varieties of herpesvirus. Amyloid-β is an antimicrobial peptide, a part of the innate immune response, and one could argue that persistently raised expression of amyloid-β will increase misfolding and generation of the … Read more
If all the excitement of NCAA March Madness has you newly invested in women’s basketball, you’re not alone. Literally millions of other Americans have jumped on board too, thanks in no small part to the fervor surrounding the tournament—and the spotlight shining on amazing athletes like Caitlin Clark, Paige Bueckers, Angel Reese, and others. The … Read more
Thymocytes generated in the bone marrow migrate to the thymus, near the heart, where they mature into T cells of the adaptive immune system. Unfortunately, the thymus atrophies with age. Most people have little active thymus tissue left by the time they are in their 50s. Absent a robust supply of new T cells, … Read more